42336159-CHIMIOTERAPIA-ANTICANCEROASA

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  Article I. CHIMIOTERAPIA ANTICANCEROASA (CITOSTATICELE) Article II. Section II.1 Section II.2 Section II.3 Section II.4 Definitie  SM utilizate în bolile neoplazice  scop de a:   distruge celulele canceroa roase opri prolife liferarea acestora Article III. Section III.1 Section III.2 Tumora malignă este o populaţie celulară heterogenă formată din 3 tipuri de celule: Section III.3 celule în faza de diviziune celulară influenţate de citostatice; Section III.4 celule în repaus (Go) rezisten
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  1 SecSectitionon II.1II.1SecSectitionon II.2II.2SecSectitionon II.3II.3 AArrttiiccllee II.. CCHHIIMMIIOOTETERARAPPIIAAANANTTIICCANCANCEER R OOAASSAA((CICITTOOSSTTAATTIICCELE)ELE) AArrttiiccllee III.I. SSecectitioonn II.II.44 DDeefifinnitiitiee  ν ν   SSMM uuttiilliizazattee  î  î nn bobollililee neopneopllaazziicece  ν ν   scopscop dede a:a:  ν ν   ddiissttr r uuggee cceelluulleelele ccaanncceeroroaasese  ν ν   ooppr r ii ppr r oolif lif eer r aar r eeaa aacceessttoor r aa SecSectitionon IIIIII.1.1 AArrttiiccllee IIII.II. SecSectitionon IIIIII.2.2 TTuummoorara mamaliligngnăă esesttee oo popupopullaaţţiiee cecelluullaar r ăăhehetteer r ogenăogenă f f oormrmaattăă ddiinn 33 ttiipupur r ii dede cceelluulle:e: SecSectitionon IIIIII.3.3 cecelluullee  î  î nn f f azaaza dede ddiivviizziiuneune cecelluullaar r ăă iinnf f lluenuenţţaattee dede cciittososttaattiice;ce; SecSectitionon IIIIII.4.4 cecelluullee  î  î nn r r epausepaus (G(Goo r r eezziissttenenttee llaa cciittososttaattiice;ce; SecSectitionon IIIIII.5.5 cecelluullee cacar r ee !!ii auau ppiieer r dutdut capaccapaciittaatteaea dede ddiivviizziiuneune r r ezeziissttenenttee llaa cciittososttaattiice#ce#SSececttiionon $$$#$$$#%%SSececttiionon $$$#$$$#&& AArrticleticle IIV.V. SecSectitionon IIVV.1.1 'itos'itosttaticeleaticele acţioacţionneazăează asuasuppr r aa celulecelulellor or cancancceer r oaseoase ppr r inin mmaiai mmululttee mmecaecannisismmee  iinnteter r f f eer r andand ccuu ciclulciclul celular celular ))**ooppr r escesc celulacelula dindin ppr r olifeolifer r aar r ee sisi eevventualentual oo ddististr r ug:ug:SSectionection $$++#,#, aa altalteer r aar r eeaa mmolecuoleculleiei dede  - -././ ppr r ef ef oormrmaatete cucu ooppr r iir r eaeappr r ocesuluiocesului ddee ttr r aanscnscr r ipţieipţie ddee  - -./;./;SSectionection $$++#3#3 bb intinteer r fefer r aar r eaea bbiiosintezeiosintezei dede  - -././  - -0/0/ !i!i aa ppr r oteineloteineloor r ;;SSectionection $$++#1#1 cc altealter r aar r eaea ttubulineiubulinei ppr r ooteinăteină dindin ccoommpoziţiapoziţia aapapar r atuluiatuluimmitoticitotic celulcelulaar r ## SectionSection IIV.5V.5 AArrttiiccllee VV..  SecSectitionon VV.1.1SecSectitionon VV.2.2SecSectitionon VV.3.3 ''iittootto2o2iicciittaatteaea ananttiicancecancer r oaseoaselloor r :: SecSectitionon VV.4.4 e2pe2plliicacattăă ppr r iinn mmaiai mmuullttee mmecanecaniissmme;e; SecSectitionon VV.5.5 cciittososttaattiicecellee oommoaoar r ăă cceelluulleellee mmaalliignegne aaf f llaattee  î  î nnf f azaaza dede ddiivviizziiuneune cecelluullaar r ăă (î (î nn r r epausepaus scapăscapă dede subsub acacţţiiuneauneacciittososttaattiicecelloorr## AArrttiiccllee VVI.I. SecSectitionon VIVI.1.1 FFaazzoo -- ddeeppeennddeennţţaa ccititoossttaatiticecelloor r  :: SecSectitionon VIVI.2.2 cciiccllulul cecelluullar ar esesttee ddiivviizatzat  î  î nn 11 f f azeazeSSececttiionon ++$#$#33SSececttiionon ++$#$#11SSececttiionon ++$#$# SecSectitionon VIVI.6.6 GG44 )) iinntteerf rf azaazaSSececttiionon ++$#$#&& SS )) ssiinnttezaeza dede  - -..// SecSectitionon VIVI.8.8 GG,, )) peper r iioadaoada ddiinntr tr ee ssiinnttezaeza dede  - -..// !i!i mmiittozăozăSSececttiionon ++$#$#55 MM )) mmiittozaozaSSececttiionon ++$#$#4646 GG66 )) cecelluullee aaf f llaattee  î  î nn r r epausepaus AArrttiiccllee VVII.II. SSececttiionon ++$$#$$#44  7  7 nn f f uncuncţţiiee dede acacţţiiuneaunea cciittososttaattiicăcă  î  î nn cucur r sulsul cciicclluulluiuicceelluullar ar ddiissttiingengemm::SSececttiionon ++$$#$$#,, aa 'i'ittososttaattiicece f f azoazo dependendependenttee ((acacţţiioneazăonează  î  î nntr tr  ooanuanummiittaa f f azăază aa cciicclluulluiui cecelluullaarr:: SecSectitionon VIIVII.3.3  - -nnttiimmeettaboaboliliţiţiii f f azaaza 88SS88 SecSectitionon VIIVII.4.4 +i+incncr r iissttiinana f f azaaza 88MM88 SecSectitionon VIIVII.5.5 9l9leoeommiicciinana f f azaaza 88GG88SSececttiionon ++$$#$$#%% bb 'i'ittososttaattiicece cciicclloo dependendependenttee ((acacţţiioneazăonează pepe ttototpapar r cucur r sulsul cciicclluulluiui cecelluullaar r  SecSectitionon VIIVII.7.7  - -gengenţţiiii aallcchhililananţţii AArrttiiccllee VVIII.III. SecSectitionon VIIIVIII.1.1 NNeseesellecectitivviittaatteaea  SecSectitionon XX.17.17 &lop&lopececiiaa :: fr fr ececvvenenttăă r r eevveer r ssibilăibilă;; ssuur r vvininee dupdupăă aa 4646 aa zzii ddee tr tr aattamameennt#t# SecSectitionon XX.18.18  -f  -f eeccttaar r eeaa ggameametotoggeenneezezei'i' hipohiposspeper r miemie ameamennoor r eeee hihippoof f eer r ttiliilittaatete AArrttiiccllee XXI.I. SecSectitionon XIXI.1.1SecSectitionon XIXI.2.2 SSececttiionon $#$#33 bb f f ececttee ttaar r ddiive:ve: uneouneor r ii iir r eveever r ssiibbiillee SecSectitionon XIXI.4.4 hepahepattootto2o2iicciittaatteecacar r ddiiootto2o2iicciittaattee SecSectitionon XIXI.5.5 nenefr fr ootto2o2iicciittaatteetteer r aattogenogeniittaattee SecSectitionon XIXI.6.6 tto2o2iicciittaattee pupullmmonaonar r ăă f f iibbr r ozăozăppuullmmonaonar r ăă AArrttiiccllee XXII.II. SecSectitionon XIIXII.1.1 ononttraraiindndiicacaţiţiii :: SecSectitionon XIIXII.2.2 ttuummoor r ii llococaalilizazattee cacar r ee potpot f f ii e2e2ttiir r papattee cchhiir r uur r ggiicalcal !i!ir r ăspundăspund f f avoavor r ababiill llaa 0022 tteer r apapiiee SecSectitionon XIIXII.3.3 depdepr r iimmaar r ee mmeduedullaar r ăă sevesever r ăă ((lleucoceucociittee subsub36663666AmmAmm33 !i!i nunummăăr r ulul dede tr tr oommbocbociittee subsub 66##666666 mmmm33;; SecSectitionon XIIXII.4.4 sasar r cciinănă ((potpot acacttiionaona tto2o2iicc asupasupr r aa eemmbbr r iionuonulluuii))**mmaallf f oormrmaattiiii avoavortrtSSececttiionon $$#$$# $$nn ssttadadiiuull tteermrmiinalnal alal neopneopllasasmmuulluuiiSSececttiionon $$#$$#%% BBr r udenudenttaa llaa babatr tr aniani AArrttiiccllee XXIII.III. SSecectitioonn XXIII.III. ()()ININ II((IIII**++ TT))&&TT&&,,+N+NTT!*!!*!II IITTSTST&&TTII SSececttiionon $$$#$$$#,, BBenentr tr uu aallegeeger r eaea uneiunei scheschemmee tteer r apeuapeuttiicece sese vavaţţiinene seaseammaa de:de:SSececttiionon $$$#$$$#33 4#4# BBaartrtiicucullaar r iittăăţţililee f f iiecăecăr r uiui bboollnav:nav:SSececttiionon $$$#$$$#11 v>v>r r sstta;a;SSececttiionon $$$#$$$# ssttaar r eaea dede nunutr tr iiţţiie;e;SSececttiionon $$$#$$$#%% ssttaar r eaea f f uncuncţţiionaonallăă aa unor unor oor r ganegane vviittaallee (f (f iicacattr r iinniichchii;; vvaalloor r ililee hehemmogogr r aammeeii;; concontr tr aaiindndiicacaţţiiii tteemmpopor r aar r ee aa cciittososttaattiicuculluiui c>ndc>nd nunummăăr r ulul dede lleucoeucocciittee SecSectitionon XIIIXIII.7.7 CC 36663666AmAm33 !i!i nunummăăr r ulul dede tr tr oommbocbociitteeesesttee
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